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T-box transcription factor TBX22; T-box protein 22 (TBX22, TBOX22)
Function:
- probable transcriptional regulator involved in developmental processes
- major determinant crucial to palatogenesis
Structure:
- contains 1 T-box DNA-binding domain
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2
Expression: seems to be expressed at a low level
Pathology:
- defects in TBX22 are the cause of X-linked cleft palate with ankyloglossia
General
T-box (TBX) protein
Properties
SIZE: entity length = 520 aa
MW = 58 kD
COMPARTMENT: cell nucleus
MOTIF: T-box domain
SITE: 96-283
Database Correlations
OMIM correlations
MORBIDMAP 300307
UniProt Q9Y458
Pfam PF00907
Entrez Gene 50945
Kegg hsa:50945
References
- UniProt :accession Q9Y458
- Entrez Gene :accession 50945