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T-box transcription factor TBX21; T-box protein 21; T-cell-specific T-box transcription factor T-bet; transcription factor TBLYM (TBX21, TBET, TBLYM)
Function:
- facilitates conversion of T helper-2 (Th2) cells into T helper-1 (Th1) cells
- controls expression of the TH1 cytokine, interferon-gamma
- initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs & by repressing the opposing TH2 programs
Structure:
- contains 1 T-box DNA-binding domain
Compartment: nucleus
Expression: T-cell specific
Pathology:
- T-bet is found in low concentrations in airways of humans with asthma [2]
Related
T-bet gene
General
T-box (TBX) protein
Properties
SIZE: entity length = 535 aa
MW = 58 kD
COMPARTMENT: cell nucleus
MOTIF: T-box domain
SITE: 141-326
Database Correlations
OMIM correlations
UniProt Q9UL17
Pfam PF00907
Entrez Gene 30009
Kegg hsa:30009
References
- UniProt :accession Q9UL17
- Finotto S et al,
Development of spontaneous airway changes consistent with
human asthma in mice lacking T-bet.
Science 295:336, 2002
PMID: 11786643
- Szabo SJ et al,
Distinct effects of T-bet in TH1 lineage commitment of
IFN-gamma production in CD4 and CD8 T cells.
Science 295:338, 2002
PMID: 11786644
- Vogel G,
Asthma research. Missing gene takes mice's breath away.
Science 295:253, 2002
PMID: 11786617
- Entrez Gene :accession 30009