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T-box transcription factor TBX2; T-box protein 2 (TBX2)
Function:
- role in transcriptional regulation of genes required for mesoderm differentiation
- probably plays a role in limb pattern formation
Structure: contains 1 T-box DNA-binding domain
Compartment: nucleus (putative)
Expression:
- expressed primarily in adult in kidney, lung, & placenta
- weak expression in heart & ovary
General
T-box (TBX) protein
Properties
SIZE: entity length = 712 aa
MW = 75 kD
COMPARTMENT: cell nucleus
MOTIF: alanine-rich region {28-87}
MOTIF: alanine residue (SEVERAL)
T-box domain
SITE: 109-287
glycine-rich region {461-538}
alanine-rich region {581-603}
MOTIF: alanine residue (SEVERAL)
Database Correlations
OMIM 600747
UniProt Q13207
PFAM correlations
Entrez Gene 6909
Kegg hsa:6909
References
- UniProt :accession Q13207
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/TBX2ID42485ch17q23.html