Search
Tyrosine-protein phosphatase non-receptor type 20 (hPTPN20a, PTPN20A)
Function:
- tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli
- has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates
- phosphorylated upon DNA damage, probably by ATM or ATR
protein tyrosine phosphate + H2O
protein tyrosine + phosphate
Structure:
- belongs to the protein-tyrosine phosphatase family non-receptor class subfamily
- contains 1 tyrosine-protein phosphatase domain
Compartment:
- nucleus, cytoplasm
- colocalizes with microtubule-organizing center & intracellular membrane compartments
Alternative splicing: named isoforms=15
Expression:
- present in many cell lines (at protein level)
- widely expressed
General
nuclear protein
phosphoprotein
phosphoprotein phosphatase
Properties
SIZE: entity length = 420 aa
MW = 48 kD
COMPARTMENT: cell nucleus
STATE: active state
MOTIF: Ser phosphorylation site {S105}
active site
Tyrosine-protein phosphatase {159-412}
MOTIF: cysteine residue {C353}
Database Correlations
UniProt Q4JDL3
Pfam PF00102
ENZYME 3.1.3.48
References
UniProt :accession Q4JDL3