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discoidin domain-containing receptor 2; discoidin domain receptor 2; receptor protein-tyrosine kinase TKT; tyrosine-protein kinase TYRO10; neurotrophic tyrosine kinase, receptor-related 3; CD167 antigen-like family member B; CD167b (DDR2, NTRKR3, TKT, TYRO10)
Function:
- tyrosine kinase receptor for fibrillar collagen
- mediates fibroblast migration & proliferation
- contributes to cutaneous wound healing (putative)
Structure:
- belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
- contains 1 F5/8 type C domain
- contains 1 protein kinase domain
Compartment: membrane
Expression:
- the major 10 kD transcript is expressed in high levels in heart & lung, less in brain, placenta, liver, skeletal muscle, pancreas, & kidney
General
glycoprotein
tyrosine kinase receptor (RTK)
Properties
SIZE: entity length = 855 aa
MW = 97 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-21}
coagulation factors 5/8 type C domain (FA58C) {30-185}
MOTIF: cysteine residue {C30}
MODIFICATION: cysteine residue {C185}
cysteine residue {C73}
MODIFICATION: cysteine residue {C177}
N-glycosylation site {N121}
cysteine residue {C177}
MODIFICATION: cysteine residue {C73}
cysteine residue {C185}
MODIFICATION: cysteine residue {C30}
N-glycosylation site {N213}
N-glycosylation site {N261}
N-glycosylation site {N280}
N-glycosylation site {N372}
transmembrane domain {400-421}
kinase domain
SITE: 563-849
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 569-577
ATP-binding site
NAME: ATP-binding site
SITE: 608-608
aspartate residue {D710}
Tyr phosphorylation site {Y736}
Tyr phosphorylation site {Y740}
Database Correlations
OMIM 191311
MORBIDMAP 191311
UniProt Q16832
PFAM correlations
Kegg hsa:4921
ENZYME 2.7.10.1
References
UniProt :accession Q16832