tyrosine-protein kinase STYK1; novel oncogene with kinase domain; protein PK-unique; serine/threonine/tyrosine kinase 1 (STYK1, NOK)

Function: - probable tyrosine protein kinase - may act by activating both MAP kinase & PI3K pathways Structure: - belongs to the protein kinase superfamily, tyrosine protein kinase family - contains 1 protein kinase domain Compartment: membrane (potential) Expression: - widely expressed - highly expressed in brain, placenta & prostate - undetectable in most normal lung tissue (see Pathology) Pathology: - transforming capabilities on a variety of cell lines - when overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs - expressed in tumor cells such as hepatoma cells LO2, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 & chronic myelogenous leukemia cells K562, but not in other tumor cells such as epidermoid carcinoma (A431) - widely expressed in lung cancers (see Expression)

General

membrane protein tyrosine kinase (protein tyrosine kinase, PTK)

Properties

SIZE: entity length = 422 aa MW = 48 kD COMPARTMENT: cellular membrane MOTIF: transmembrane domain {26-46} kinase domain SITE: 114-384 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 120-128 ATP-binding site NAME: ATP-binding site SITE: 147-147 aspartate residue {D251} STATE: active state

Database Correlations

OMIM 611433 UniProt Q6J9G0 Pfam PF07714 Entrez Gene 55359 Kegg hsa:55359 ENZYME 2.7.10.2

References

UniProt :accession Q6J9G0