receptor-type tyrosine-protein phosphatase zeta; R-PTP-zeta; protein-tyrosine phosphatase receptor type Z polypeptide 1; protein-tyrosine phosphatase receptor type Z polypeptide 2; R-PTP-zeta-2 (PTPRZ1 HTPZP2 PTPRZ PTPRZ2 PTPZ)

Function: - may be involved in the regulation of specific developmental processes in the CNS - the carbonic-anhydrase like domain binds to contactin protein tyrosine phosphate + H₂O = protein tyrosine + phosphate Structure: - belongs to the protein-tyrosine phosphatase family receptor class 5 subfamily - contains 1 alpha-carbonic anhydrase domain - contains 1 fibronectin F3 module - contains 2 tyrosine-protein phosphatase domains Compartment: - membrane; single-pass type 1 membrane protein Alternative splicing: named isoforms=2; long, short Expression: - specifically expressed in the central nervous system, where it is localized in the purkinje cell layer of the cerebellum, the dentate gyrus, & the subependymal layer of the anterior horn of the lateral ventricle - developmentally regulated in the brain Notes: - formerly termed RPTPase beta - the human genome was initially thought to contain 2 genes for PTPRZ: PTPRZ1 (chromosome 7) & PTPRZ2 (chromosome 1); however, PTPRZ2 probably does not exist & corresponds to PTPRZ1

General

glycoprotein plasma membrane protein tyrosine phosphatase, receptor type

Properties

SIZE: entity length = 2315 aa MW = 255 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-24} Alpha-carbonic anhydrase {36-300} MOTIF: N-glycosylation site {N105} N-glycosylation site {N134} N-glycosylation site {N223} N-glycosylation site {N232} fibronectin type III domain or F3 module {311-406} MOTIF: N-glycosylation site {N324} N-glycosylation site {N381} N-glycosylation site {N497} N-glycosylation site {N501} N-glycosylation site {N552} Ser glycosylation site {S587} N-glycosylation site {N602} N-glycosylation site {N629} Ser glycosylation site {S637} N-glycosylation site {N677} Ser glycosylation site {S997} N-glycosylation site {N1017} N-glycosylation site {N1050} N-glycosylation site {N1082} N-glycosylation site {N1122} N-glycosylation site {N1457} Ser glycosylation site {S1549} Ser glycosylation site {S1551} N-glycosylation site {N1562} N-glycosylation site {N1618} transmembrane domain {1637-1662} Tyrosine-protein phosphatase 1 {1717-1992} MOTIF: binding site SITE: 1901-1901 FOR-BINDING-OF: Substrate Substrate binding {1933-1939} cysteine residue {C1933} binding site SITE: 1977-1977 FOR-BINDING-OF: Substrate Tyrosine-protein phosphatase 2 {2023-2282} MOTIF: aspartate residue {2223} STATE: active state

Database Correlations

OMIM correlations UniProt P23471 PFAM correlations Entrez Gene 5803 Kegg hsa:5803 ENZYME 3.1.3.48