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receptor-type tyrosine-protein phosphatase mu; protein-tyrosine phosphatase mu; R-PTP-mu (PTPRM, PTPRL1)
Function:
- role in cell-cell adhesion through homophilic interactions
- may play a key role in signal transduction & growth control
protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Structure:
- belongs to the protein-tyrosine phosphatase family receptor class 2B subfamily
- contains 4 fibronectin F3 modules
- contains 1 Ig-like C2-type domain
- contains 1 MAM domain
- contains 2 tyrosine-protein phosphatase domains
Compartment:
- membrane; single-pass type 1 membrane protein
General
glycoprotein
plasma membrane protein
tyrosine phosphatase, receptor type
Properties
SIZE: entity length = 1452 aa
MW = 164 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-20}
MAM domain {22-184}
MOTIF: cysteine residue {*1} (2)
MODIFICATION: cysteine residue {*2}
cysteine residue {*2} (2)
MODIFICATION: cysteine residue {*1}
cysteine residue {C27}
MODIFICATION: cysteine residue {C36}
cysteine residue {C36}
MODIFICATION: cysteine residue {C27}
N-glycosylation site {N72}
N-glycosylation site {N92}
cysteine residue {C96}
MODIFICATION: cysteine residue {C182}
N-glycosylation site {N131}
cysteine residue {C182}
MODIFICATION: cysteine residue {C96}
immunoglobulin superfamily domain {186-277}
MOTIF: cysteine residue {C206}
MODIFICATION: cysteine residue {C260}
N-glycosylation site {N249}
cysteine residue {C260}
MODIFICATION: cysteine residue {C206}
fibronectin type III domain or F3 module {281-371}
fibronectin type III domain or F3 module {379-477}
MOTIF: N-glycosylation site {N406}
N-glycosylation site {N414}
N-glycosylation site {N454}
fibronectin type III domain or F3 module {482-581}
MOTIF: N-glycosylation site {N534}
N-glycosylation site {N544}
fibronectin type III domain or F3 module {589-671}
MOTIF: N-glycosylation site {N598}
N-glycosylation site {N651}
N-glycosylation site {N681}
transmembrane domain {743-764}
Ser phosphorylation site {S821}
Ser phosphorylation site {S824}
Tyrosine-protein phosphatase 1 {900-1154}
MOTIF: binding site
SITE: 1063-1063
FOR-BINDING-OF: Substrate
Substrate binding {1095-1101}
cysteine residue {C1095}
binding site
SITE: 1139-1139
FOR-BINDING-OF: Substrate
Tyrosine-protein phosphatase 2 {1186-1448}
MOTIF: cysteine residue {C1389}
STATE: active state
Database Correlations
OMIM 176888
UniProt P28827
PFAM correlations
Entrez Gene 5797
Kegg hsa:5797
ENZYME 3.1.3.48
References
UniProt :accession P28827