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receptor-type tyrosine-protein phosphatase kappa; protein-tyrosine phosphatase kappa; R-PTP-kappa (PTPRK, PTPK)
Function:
- regulation of processes involving cell contact & adhesion such as growth control, tumor invasion, & metastasis
- forms complexes with beta-catenin & gamma-catenin/plakoglobin
- beta-catenin may be a substrate for the catalytic activity of PTP- kappa
- undergoes proteolytic processing
protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Structure:
- belongs to the protein-tyrosine phosphatase family receptor class 2B subfamily
- contains 4 fibronectin F3 modules
- contains 1 Ig-like C2-type domain
- contains 1 MAM domain
- contains 2 tyrosine-protein phosphatase domains
Compartment:
- cell junction, adherens junction
- cell membrane; single-pass type 1 membrane protein
Alternative splicing: named isoforms=2
Expression:
- high levels in lung, brain & colon
- less expression in liver, pancreas, stomach, kidney, placenta & mammary carcinoma
General
glycoprotein
plasma membrane protein
tyrosine phosphatase, receptor type
Properties
SIZE: entity length = 1439 aa
MW = 162 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-26}
MAM domain {31-194}
MOTIF: cysteine residue {*1} (2)
MODIFICATION: cysteine residue {*2}
cysteine residue {*2} (2)
MODIFICATION: cysteine residue {*1}
N-glycosylation site {N101}
N-glycosylation site {N140}
immunoglobulin superfamily domain {196-281}
MOTIF: N-glycosylation site {N211}
cysteine residue {C216}
MODIFICATION: cysteine residue {C270}
cysteine residue {C270}
MODIFICATION: cysteine residue {C216}
fibronectin type III domain or F3 module {291-383}
fibronectin type III domain or F3 module {389-485}
MOTIF: N-glycosylation site {N416}
N-glycosylation site {N424}
N-glycosylation site {N436}
N-glycosylation site {N462}
fibronectin type III domain or F3 module {490-589}
MOTIF: N-glycosylation site {N552}
N-glycosylation site {N586}
N-glycosylation site {N590}
fibronectin type III domain or F3 module {597-680}
MOTIF: N-glycosylation site {N607}
proteolytic site {643-644}
N-glycosylation site {N690}
transmembrane domain {753-774}
Tyr phosphorylation site {Y805}
Tyr phosphorylation site {Y858}
Tyrosine-protein phosphatase 1 {887-1141}
MOTIF: binding site
SITE: 1050-1050
FOR-BINDING-OF: Substrate
Substrate binding {1082-1088}
cysteine residue {C1082}
binding site
SITE: 1126-1126
FOR-BINDING-OF: Substrate
Tyrosine-protein phosphatase 2 {1173-1435}
MOTIF: cysteine residue {C1376}
STATE: active state
Database Correlations
OMIM 602545
UniProt Q15262
PFAM correlations
Entrez Gene 5796
Kegg hsa:5796
ENZYME 3.1.3.48
References
UniProt :accession Q15262