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receptor-type tyrosine-protein phosphatase gamma; protein-tyrosine phosphatase gamma; R-PTP-gamma (PTPRG, PTPG)
Function:
- possesses tyrosine phosphatase activity
- monomer: active form; homodimer: inactive form (probable)
protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Structure:
- belongs to the protein-tyrosine phosphatase family receptor class 5 subfamily
- contains 1 alpha-carbonic anhydrase domain
- contains 1 fibronectin F3 module
- contains 2 tyrosine-protein phosphatase domains
Compartment:
- membrane; single-pass type 1 membrane protein (probable)
Alternative splicing: named isoforms=2
Expression: found in a variety of tissues
General
glycoprotein
plasma membrane protein
tyrosine phosphatase, receptor type
Properties
SIZE: entity length = 1445 aa
MW = 162 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
Alpha-carbonic anhydrase {58-321}
MOTIF: N-glycosylation site {N109}
N-glycosylation site {N113}
Thr phosphorylation site {T115}
N-glycosylation site {N156}
fibronectin type III domain or F3 module {346-443}
MOTIF: N-glycosylation site {N359}
N-glycosylation site {N444}
N-glycosylation site {N619}
N-glycosylation site {N631}
N-glycosylation site {N722}
transmembrane domain {737-762}
Tyrosine-protein phosphatase 1 {848-1119}
MOTIF: binding site
SITE: 1028-1028
FOR-BINDING-OF: Substrate
Substrate binding {1060-1066}
cysteine residue {C1060}
binding site
SITE: 1104-1104
FOR-BINDING-OF: Substrate
Tyrosine-protein phosphatase 2 {1150-1410}
MOTIF: aspartate residue {1351}
Ser phosphorylation site {S1435}
STATE: active state
Database Correlations
OMIM 176886
UniProt P23470
PFAM correlations
Entrez Gene 5793
Kegg hsa:5793
ENZYME 3.1.3.48
References
- UniProt :accession P23470
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/PTPRGID41930ch3p21.html