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receptor-type tyrosine-protein phosphatase delta; protein-tyrosine phosphatase delta; R-PTP-delta (PTPRD)
Function:
- tyrosine phosphatase
- undergoes 'ectodomain shedding'
- interacts with PPFIA1, PPFIA2 & PPFIA3
protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Structure:
- belongs to the protein-tyrosine phosphatase family receptor class 2A subfamily
- contains 8 fibronectin F3 modules
- contains 3 Ig-like C2-type domains
- contains 2 tyrosine-protein phosphatase domains
Compartment:
- membrane; single-pass type 1 membrane protein
Alternative splicing:
- named isoforms=3
- additional isoforms seem to exist
- at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense- mediated mRNA decay
General
glycoprotein
plasma membrane protein
tyrosine phosphatase, receptor type
Properties
SIZE: entity length = 1912 aa
MW = 215 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-20}
immunoglobulin superfamily domain {24-114}
MOTIF: cysteine residue {C45}
MODIFICATION: cysteine residue {C98}
cysteine residue {C98}
MODIFICATION: cysteine residue {C45}
immunoglobulin superfamily domain {126-224}
MOTIF: cysteine residue {C147}
MODIFICATION: cysteine residue {C207}
cysteine residue {C207}
MODIFICATION: cysteine residue {C147}
immunoglobulin superfamily domain {236-318}
MOTIF: N-glycosylation site {N254}
cysteine residue {C257}
MODIFICATION: cysteine residue {C302}
N-glycosylation site {N299}
cysteine residue {C302}
MODIFICATION: cysteine residue {C257}
fibronectin type III domain or F3 module {323-411}
fibronectin type III domain or F3 module {417-511}
fibronectin type III domain or F3 module {516-604}
fibronectin type III domain or F3 module {609-706}
fibronectin type III domain or F3 module {711-819}
MOTIF: N-glycosylation site {N724}
fibronectin type III domain or F3 module {824-913}
MOTIF: N-glycosylation site {N832}
fibronectin type III domain or F3 module {918-1013}
fibronectin type III domain or F3 module {1017-1103}
proteolytic site {1181-1182}
transmembrane domain {1266-1290}
Tyrosine-protein phosphatase 1 {1357-1612}
MOTIF: binding site
SITE: 1521-1521
FOR-BINDING-OF: Substrate
Substrate binding {1553-1559}
cysteine residue {C1553}
binding site
SITE: 1597-1597
FOR-BINDING-OF: Substrate
Tyrosine-protein phosphatase 2 {1644-1903}
MOTIF: cysteine residue {C1844}
STATE: active state
Database Correlations
OMIM 601598
UniProt P23468
PFAM correlations
Entrez Gene 5789
KEGG correlations
ENZYME 3.1.3.48
References
- UniProt :accession P23468
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/PTPRDID41927ch9p23.html