receptor-type tyrosine-protein phosphatase beta; protein-tyrosine phosphatase beta; R-PTP-beta; vascular endothelial protein tyrosine phosphatase; VE-PTP (PTPRB, PTPB)

Function: - plays an important role in blood vessel remodeling & angiogenesis - not necessary for the initial formation of blood vessels, but is essential for their maintenance & remodeling - can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin & KDR/VEGFR-2 - regulates angiopoietin-TIE2 signaling in endothelial cells - acts as a negative regulator of TIE2, & controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development & determines blood vessel size during perinatal growth - essential for the maintenance of endothelial cell contact integrity & for the adhesive function of VE-cadherin in endothelial cells & this requires the presence of plakoglobin (putative) - interacts with TEK - interacts via fibronectin type-III 17 domain with CDH5 (putative) protein tyrosine phosphate + H₂O = protein tyrosine + phosphate Structure: - monomer - belongs to the protein-tyrosine phosphatase family receptor class 3 subfamily - contains 17 fibronectin F3 modules - contains 1 tyrosine-protein phosphatase domain Compartment: - membrane; single-pass type 1 membrane protein (putative) Alternative splicing: named isoforms=3 Expression: up-regulated by hypoxia

General

glycoprotein plasma membrane protein tyrosine phosphatase, receptor type

Properties

SIZE: entity length = 1997 aa MW = 224 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-22} fibronectin type III domain or F3 module {23-108} MOTIF: N-glycosylation site {N28} N-glycosylation site {N53} N-glycosylation site {N75} fibronectin type III domain or F3 module {110-201} MOTIF: N-glycosylation site {N172} N-glycosylation site {N198} fibronectin type III domain or F3 module {203-288} MOTIF: N-glycosylation site {N267} fibronectin type III domain or F3 module {289-375} MOTIF: N-glycosylation site {N321} fibronectin type III domain or F3 module {377-465} MOTIF: N-glycosylation site {N414} N-glycosylation site {N421} fibronectin type III domain or F3 module {467-552} MOTIF: N-glycosylation site {N479} N-glycosylation site {N544} fibronectin type III domain or F3 module {554-641} MOTIF: N-glycosylation site {N574} N-glycosylation site {N598} fibronectin type III domain or F3 module {643-730} MOTIF: N-glycosylation site {N652} N-glycosylation site {N721} fibronectin type III domain or F3 module {731-817} fibronectin type III domain or F3 module {819-906} MOTIF: N-glycosylation site {N829} fibronectin type III domain or F3 module {907-993} fibronectin type III domain or F3 module {995-1083} MOTIF: N-glycosylation site {N1040} Thr phosphorylation site {T1067} Ser phosphorylation site {S1069} fibronectin type III domain or F3 module {1085-1172} MOTIF: N-glycosylation site {N1096} N-glycosylation site {N1163} fibronectin type III domain or F3 module {1173-1260} MOTIF: N-glycosylation site {N1185} N-glycosylation site {N1212} fibronectin type III domain or F3 module {1261-1353} MOTIF: N-glycosylation site {N1274} fibronectin type III domain or F3 module {1355-1443} MOTIF: N-glycosylation site {N1367} fibronectin type III domain or F3 module {1448-1550} MOTIF: N-glycosylation site {N1470} N-glycosylation site {N1474} N-glycosylation site {N1518} transmembrane domain {1622-1642} Ser phosphorylation site {S1647} Tyrosine-protein phosphatase {1703-1963} MOTIF: binding site SITE: 1870-1870 FOR-BINDING-OF: Substrate Substrate binding {1904-1910} cysteine residue {C1904} binding site SITE: 1948-1948 FOR-BINDING-OF: Substrate STATE: active state

Database Correlations

OMIM 176882 UniProt P23467 PFAM correlations Entrez Gene 5787 Kegg hsa:5787 ENZYME 3.1.3.48

References

UniProt :accession P23467