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receptor-type tyrosine-protein phosphatase alpha; protein-tyrosine phosphatase alpha; R-PTP-alpha (PTPRA, PTPA, PTPRL2)

Function: protein tyrosine phosphate + H2O = protein tyrosine + phosphate Structure: - belongs to the protein-tyrosine phosphatase family receptor class 4 subfamily - contains 2 tyrosine-protein phosphatase domains Compartment: - membrane; single-pass type 1 membrane protein Alternative splicing: named isoforms=4

Related

gene

General

cell surface receptor glycoprotein tyrosine phosphatase, receptor type

Properties

SIZE: entity length = 802 aa MW = 91 kD COMPARTMENT: cellular membrane STATE: active state MOTIF: signal sequence {1-19} N-glycosylation site {N21} N-glycosylation site {N36} N-glycosylation site {N68} N-glycosylation site {N80} N-glycosylation site {N86} N-glycosylation site {N104} N-glycosylation site {N124} transmembrane domain {143-165} Ser phosphorylation site {S180} Ser phosphorylation site {S189} Ser phosphorylation site {S213} Tyrosine-protein phosphatase {241-501} MOTIF: binding site SITE: 410-410 FOR-BINDING-OF: Substrate Substrate binding {442-448} cysteine residue {C442} binding site SITE: 486-486 FOR-BINDING-OF: Substrate Tyrosine-protein phosphatase {533-791} MOTIF: cysteine residue {C732} Tyr phosphorylation site {Y798}

Database Correlations

OMIM 176884 UniProt P18433 Pfam PF00102 Entrez Gene 5786 Kegg hsa:5786 ENZYME 3.1.3.48

References

  1. UniProt :accession P18433
  2. Sap J et al Cloning and expression of a widely expressed receptor tyrosine phosphatase. Proc Natl Acad Sci U S A. 1990 Aug;87(16):6112-6. PMID: 2166945