tyrosine-protein kinase receptor TYRO3; tyrosine-protein kinase RSE; tyrosine-protein kinase SKY; tyrosine-protein kinase DTK; tyrosine-protein kinase byk (TYRO3, BYK, DTK, RSE, SKY)

Function: - may be involved in cell adhesion processes, especially in the central nervous system Structure: - monomer & homodimer - interacts with GAS6 - belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily - contains 2 fibronectin F3 modules - contains 2 Ig-like C2-type domains (immunoglobulin-like) - contains 1 protein kinase domain Compartment: cell membrane Expression: - abundant in the brain - lower levels in other tissues Pathology: - cell entry factor in ilovirus infection (putative)

Properties

SIZE: entity length = 890 aa MW = 97 kD COMPARTMENT: cellular membrane STATE: active state MOTIF: signal sequence {1-40} immunoglobulin superfamily domain {41-128} MOTIF: N-glycosylation site {N63} cysteine residue {C64} MODIFICATION: cysteine residue {C117} cysteine residue {C117} MODIFICATION: cysteine residue {C64} immunoglobulin superfamily domain {139-220} MOTIF: cysteine residue {C160} MODIFICATION: cysteine residue {C203} N-glycosylation site {N191} cysteine residue {C203} MODIFICATION: cysteine residue {C160} fibronectin type III domain or F3 module {225-317} MOTIF: N-glycosylation site {N230} N-glycosylation site {N240} N-glycosylation site {N293} fibronectin type III domain or F3 module {322-413} MOTIF: N-glycosylation site {N366} N-glycosylation site {N380} transmembrane domain {430-450} kinase domain SITE: 518-790 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 524-532 ATP-binding site NAME: ATP-binding site SITE: 550-550 aspartate residue {D655} Tyr phosphorylation site {Y685} Tyr phosphorylation site {Y686}

Database Correlations

OMIM 600341 UniProt Q06418 PFAM correlations Entrez Gene 7301 Kegg hsa:7301 ENZYME 2.7.10.1

References

UniProt :accession Q06418OMIM :accession 600341