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twisted gastrulation protein homolog 1 (TWSG1, TSG, PSEC0250)
Function:
- role in dorsoventral axis formation
- antagonizes BMP signaling by forming ternary complexes with CHRD & BMPs, thus preventing BMPs from binding to their receptors
- also has pro-BMP activity, partly mediated by cleavage & degradation of CHRD, which releases BMPs from ternary complexes
- modulates BMP-regulated cartilage development & chondrocyte differentiation
- role in thymocyte development
- interaction with CHRD & BMP4 enhances CHRD/BMP4 complex formation
- interacts with BMP7
Structure:
- belongs to the twisted gastrulation protein family
- N-terminal domain is sufficient to interact with BMP4
Compartment: secreted
Alternative splicing: named isoforms=2
Expression:
- expressed in brain throughout development
General
secreted protein
Properties
SIZE: MW = 25 kD
entity length = 223 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-25}
cysteine-rich region {26-77}
MOTIF: N-glycosylation site {N52}
N-glycosylation site {N81}
Database Correlations
OMIM 605049
UniProt Q9GZX9
Pfam PF04668
References
UniProt :accession Q9GZX9