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twinfilin-2; A6-related protein; hA6RP; protein tyrosine kinase 9-like; twinfilin-1-like protein (TWF2, PTK9L, MSTP011)
Function:
1) actin-binding protein
2) motile & morphological processes
3) inhibits actin polymerization, sequesters G-actin
4) capping the barbed ends of actin filaments
5) clathrin-mediated endocytosis
6) distribution of endocytic organelles
7) interacts with G-actin, ADP-actin, & actin capping protein
8) interacts with PTK9, phosphoinositides, PI(4,5)P2
9) binding to PI(4,5)P2, down-regulates
10) phosphorylated by PRKCZ, CK2, SRC
Structure:
- belongs to the actin-binding proteins ADF family Twinfilin subfamily
- contains 2 ADF-H domains
Compartment:
- cytoplasm, perinuclear
- G-actin-rich cortical actin structures
Expression: ubiquitously expressed
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: entity length = 349 aa
MW = 40 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
ADF-H 1 {4-139}
ADF-H 2 {177-313}
MOTIF: Tyr phosphorylation site {Y309}
Ser phosphorylation site {S349}
Database Correlations
OMIM 607433
UniProt Q6IBS0
Pfam PF00241
Entrez Gene 11344
Kegg hsa:11344
References
- UniProt :accession Q6IBS0
- Protein Spotlight; Note: molecular embrace - Issue 73 of
August 2006
http://web.expasy.org/spotlight/back_issues/sptlt073.shtml