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tweety homolog 2 (hTTY2, TTYH2 C17orf29)
Function:
- probable large-conductance Ca+2-activated chloride channel
- may play a role in Ca+2 signal transduction.
- may be involved in cell proliferation & cell aggregation
Structure: belongs to the tweety family
Compartment: cell membrane; Multi-pass membrane protein
Expression:
- expressed in brain & testis > heart, ovary, spleen & peripheral blood
Pathology:
- up-regulated in 13 of 16 renal cell carcinoma samples examined
- up-regulated in colon carcinoma
General
glycoprotein
phosphoprotein
transmembrane 5 protein
tweety homolog
Properties
SIZE: entity length = 534 aa
MW = 59 kD
COMPARTMENT: cell nucleus
MOTIF: exoplasmic domain {1-44}
MOTIF: N-glycosylation site {N31}
transmembrane domain {45-65}
cytoplasmic loop {66-87}
transmembrane domain {88-108}
exoplasmic loop {109-213}
MOTIF: Thr phosphorylation site {T199}
transmembrane domain {214-234}
cytoplasmic loop {235-240}
transmembrane domain {241-261}
exoplasmic loop {262-388}
MOTIF: N-glycosylation site {N283}
transmembrane domain {389-409}
cytoplasmic domain {410-534}
Database Correlations
OMIM 608855
UniProt Q9BSA4
Pfam PF04906
Entrez Gene 94015
References
UniProt :accession Q9BSA4