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tweety homolog 1 (hTTY1, TTYH1)
Function:
- probable chloride channel
- may be involved in cell adhesion (putative)
- isoform 3 may be a Ca+2-independent & swelling-activated chloride channel, possibly involved in regulation of cell volume
Structure: belongs to the tweety family
Compartment: cell membrane
Alternative splicing: named isoforms=5
Expression:
- expressed in brain, eye, ovary & testis, > muscle, placenta, liver & lung
General
glycoprotein
phosphoprotein
transmembrane 5 protein
tweety homolog
Properties
SIZE: entity length = 450 aa
MW = 49 kD
COMPARTMENT: cell nucleus
MOTIF: exoplasmic domain {1-43}
transmembrane domain {44-64}
cytoplasmic loop {65-88}
transmembrane domain {89-109}
exoplasmic loop {110-214}
MOTIF: N-glycosylation site {N130}
N-glycosylation site {N205}
transmembrane domain {215-235}
cytoplasmic loop {236-240}
transmembrane domain {241-261}
exoplasmic loop {262-390}
MOTIF: N-glycosylation site {N284}
N-glycosylation site {N355}
transmembrane domain {391-411}
cytoplasmic domain {412-450}
MOTIF: Ser phosphorylation site {S448}
Ser phosphorylation site {S449}
Database Correlations
OMIM 605784
UniProt Q9H313
Pfam PF04906
Entrez Gene 57348
References
UniProt :accession Q9H313