Search
tumor protein p53-inducible nuclear protein 1 (p53-dependent damage-inducible nuclear protein 1, p53DINP1, stress-induced protein, TP53INP1, P53DINP1, SIP)
Function:
1) promotes p53 phosphorylation on Ser-46 & subsequent apoptosis in response to double-strand DNA breaks
2) interacts with TP53, HIPK2
3) p53-dependent induction by adriamycin, gamma irradiation, H2O2, & at lower levels ultraviolet irradiation
Compartment:
- nucleus
- concentrated in PML/POD/ND10 nuclear bodies
Alternative splicing: named isoforms=2
Expression: ubiquitously expressed
General
nuclear protein
Properties
SIZE: MW = 27 kD
entity length = 240 aa
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {14-17}
MOTIF: serine residue (SEVERAL)
glutamate-rich region {20-61}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
OMIM 606185
UniProt Q96A56
References
UniProt :accession Q96A56