Search
tumor necrosis factor ligand superfamily member 18; activation-inducible TNF-related ligand; AITRL; glucocorticoid-induced TNF-related ligand; hGITRL (TNFSF18, AITRL, GITRL, TL6, UNQ149/PRO175)
Function:
- cytokine that binds to TNFRSF18/AITR/GITR
- regulates T-cell responses
- can function as costimulator & lower the threshold for T-cell activation & T-cell proliferation
- important for interactions between activated T-cells & endothelial cells
- mediates activation of NF-kappa-B
Structure:
- homodimer (putative), homotrimer
- belongs to the tumor necrosis factor family
Compartment:
- cell membrane; single-pass type 2 membrane protein
Expression:
- expressed at high levels in the small intestine, ovary, testis, kidney & endothelial cells
- up-regulated after stimulation by bacterial lipopolysaccharides (LPS)
Note:
- uncertain whether Met-1 or Met-23 is the initiator
General
glycoprotein
membrane protein
tumor necrosis factor (TNF) family protein
Properties
SIZE: entity length = 199 aa
MW = 23 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {51-71}
cysteine residue {C80}
MODIFICATION: cysteine residue {C100}
cysteine residue {C100}
MODIFICATION: cysteine residue {C80}
N-glycosylation site {N151}
N-glycosylation site {N183}
Database Correlations
OMIM 603898
UniProt Q9UNG2
Pfam PF00229
Entrez Gene 8995
Kegg hsa:8995
References
- UniProt :accession Q9UNG2
- Entrez Gene :accession 8995