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tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; vascular endothelial cell growth inhibitor (TNFSF15, TL1, VEGI)
Function:
- receptor for TNFRSF25 & TNFRSF6B. mediates activation of NF-kappa-B
- inhibits vascular endothelial growth & angiogenesis (in vitro)
- promotes activation of caspases & apoptosis
Structure:
- homotrimer
- belongs to the tumor necrosis factor family
Compartment:
- membrane; single-pass type 2 membrane protein (probable)
- secreted
Alternative splicing: named isoforms=3
Expression:
- specifically expressed in endothelial cells
- detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine & colon
- up-regulated by IL1A/interleukin-1 alpha & TNF
General
cell surface receptor
tumor necrosis factor (TNF) family protein
Properties
SIZE: entity length = 251 aa
MW = 28 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {36-56}
proteolytic site {71-72}
N-glycosylation site {N133}
cysteine residue {C162}
MODIFICATION: cysteine residue {C202}
serine residue {187}
glutamate residue {190}
cysteine residue {C202}
MODIFICATION: cysteine residue {C162}
N-glycosylation site {N229}
Database Correlations
OMIM 604052
UniProt O95150
Pfam PF00229
Entrez Gene 9966
Kegg hsa:9966
References
- UniProt :accession O95150
- Entrez Gene :accession 9966