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tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; dendritic cell-derived TNF-like molecule; TNF- & APOL-related leukocyte expressed ligand 1; TALL-1; CD257 (TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738)

Function: - cytokine that binds to TNFRSF13B/TACI & TNFRSF17/BCMA - TNFSF13/APRIL binds to the same 2 receptors - together, they form a 2 ligands -2 receptors pathway involved in stimulation of B-cell & T-cell function & the regulation of humoral immunity - a 3rd B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells & the B-cell response - isoform 2 seems to inhibit isoform 1 secretion & bioactivity (putative) - the soluble form derives from the membrane form by proteolytic processing - isoform 2 is not efficiently shed from the membrane unlike isoform 1 (putative) - isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface Structure: - N-glycosylated - homotrimer - belongs to the tumor necrosis factor family Compartment: - cell membrane; single-pass type 2 membrane protein - membrane & soluble forms identified Alternative splicing: named isoforms=2 Expression: - abundantly expressed in peripheral blood Leukocytes - specifically expressed in monocytes & macrophages - also found in the spleen, lymph node, bone marrow, T-cells & dendritic cells - lower expression in placenta, heart, lung, fetal liver, thymus, & pancreas - isoform 2 is expressed in many myeloid cell lines - up-regulated by exposure to IFNG/IFN-gamma - down-regulated by phorbol myristate acetate/ionomycin treatment

Related

tumor necrosis factor receptor superfamily member 17; CD269; B-cell maturation protein (TNFRSF17, BCM, BCMA, CD269)

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein tumor necrosis factor (TNF) family protein

Properties

SIZE: entity length = 285 aa MW = 31 kD COMPARTMENT: cellular membrane MOTIF: transmembrane domain {47-67} N-glycosylation site {N124} proteolytic site {133-134} cysteine residue {C232} MODIFICATION: cysteine residue {C245} N-glycosylation site {N242} cysteine residue {C245} MODIFICATION: cysteine residue {C232}

Database Correlations

OMIM 603969 UniProt Q9Y275 Pfam PF00229 Entrez Gene 10673 Kegg hsa:10673

References

  1. Moore PA et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 285:260-3, 1999 PMID: 10398604
  2. UniProt :accession Q9Y275, Q96RJ3
  3. Entrez Gene :accession 10673
  4. Protein Spotlight; proteic grace - Issue 77 of December 2006 http://web.expasy.org/spotlight/back_issues/sptlt077.shtml