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tumor necrosis factor ligand superfamily member 13; A proliferation-inducing ligand; APRIL; TNF- & APOL-related leukocyte expressed ligand 2; TALL-2; TNF-related death ligand 1; TRDL-1; CD256 (TNFSF13, APRIL, TALL2, ZTNF2, UNQ383/PRO715)
Function:
- cytokine that binds to TNFRSF13B/TACI & to TNFRSF17/BCMA
- may be implicated in the regulation of tumor cell growth
- may be involved in monocyte/macrophage-mediated immunological processes
- the precursor is cleaved by furin
Structure:
- homotrimer (putative)
- belongs to the tumor necrosis factor family
Compartment: secreted
Alternative splicing: named isoforms=3; alpha, beta, gamma
Expression:
- expressed at high levels in transformed cell lines, colon carcinoma, thyroid carcioma, & lymphoma
- specifically expressed in monocytes & macrophages
- down-regulated by phorbol myristate acetate/ionomycin treatment
Interactions
molecular events
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
tumor necrosis factor (TNF) family protein
Properties
SIZE: entity length = 250 aa
MW = 27 kD
COMPARTMENT: extracellular compartment
MOTIF: proteolytic site {104-105}
N-glycosylation site {N124}
cysteine residue {C196}
MODIFICATION: cysteine residue {C211}
cysteine residue {C211}
MODIFICATION: cysteine residue {C196}
Database Correlations
OMIM 604472
UniProt O75888
Pfam PF00229
Entrez Gene 8741
Kegg hsa:8741
References
- UniProt :accession O75888
- Entrez Gene :accession 8741
Component-of
molecular complex