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tumor necrosis factor-inducible protein TSG-6 (TNF-stimulated gene 6 protein, hyaluronate-binding protein, TNFAIP6, TSG6)
Function:
1) role in cell-cell & cell-matrix interactions during inflammation & tumorigenesis
2) interacts with inter-alpha-inhibitor (I-alpha-I)
- chondroitin sulfate may be required for the stability of the complex
3) induced by TNF
Structure:
- contains 1 CUB domain.
- contains 1 Link domain
Pathology:
- found in synovial fluid of patients with rheumatoid arthritis
General
glycoprotein
Properties
SIZE: MW = 31 kD
entity length = 277 aa
MOTIF: signal sequence {1-17}
Link {36-129}
MOTIF: cysteine residue {C58}
MODIFICATION: cysteine residue {C127}
cysteine residue {C82}
MODIFICATION: cysteine residue {C103}
cysteine residue {C103}
MODIFICATION: cysteine residue {C82}
N-glycosylation site {N118}
cysteine residue {C127}
MODIFICATION: cysteine residue {C58}
CUB domain {135-247}
MOTIF: cysteine residue {C135}
MODIFICATION: cysteine residue {C161}
cysteine residue {C161}
MODIFICATION: cysteine residue {C135}
cysteine residue {C188}
MODIFICATION: cysteine residue {C210}
cysteine residue {C210}
MODIFICATION: cysteine residue {C188}
N-glycosylation site {N258}
Database Correlations
OMIM 600410
UniProt P98066
PFAM correlations
References
UniProt :accession P98066