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transmembrane 4 L6 family member 1; tumor-associated antigen L6; membrane component surface marker 1; M3S1 (TM4SF1, M3S1, TAAL6)
present in high molecular weight complexes in tumor cells
Structure: belongs to the L6 tetraspanin family
Compartment: membrane
Expression:
- highly expressed on lung carcinoma, breast carcinoma, colon adenocarcinoma, & ovarian carcinoma
- also present on some normal cells, endothelial cells in particular
General
glycoprotein
plasma membrane protein
transmembrane 4 protein
Properties
SIZE: entity length = 202 aa
MW = 22 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-9}
transmembrane domain {10-30}
exoplasmic loop {31-49}
transmembrane domain {50-70}
cytoplasmic loop {71-93}
transmembrane domain {94-114}
exoplasmic loop {115-161}
MOTIF: N-glycosylation site {N129}
N-glycosylation site {N159}
transmembrane domain {162-182}
cytoplasmic domain {183-202}
Database Correlations
OMIM 191155
UniProt P30408
Pfam PF05805
Entrez Gene 4071
Kegg hsa:4071
References
UniProt :accession P30408