tubulointerstitial nephritis antigen-like (tubulointerstitial nephritis antigen-related protein, TIN Ag-related protein, TIN-Ag-RP, glucocorticoid-inducible protein 5, oxidized LDL-responsive gene 2 protein, OLRG-2, TINAGL1, GIS5, LCN7, OLRG2, TINAGL, PP6614, PSEC0088, UNQ204/PRO230)

Function: - role in adrenocortical zonation & in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells Structure: - glycosylated - belongs to the peptidase C1 family - contains 1 SMB domain (somatomedin B domain) Compartment: secreted Alternative splicing: named isoforms=2 Expression: - expressed in aorta, heart, placenta, kidney > skeletal muscle, pancreas, lung, lymph nodes, adrenal gland, bone marrow, thyroid > colon, small intestine, ovary, spleen, testis, prostate - predominantly found in vascular smooth muscle cells, but also in cardiac & skeletal muscle cells & kidney Pathology: - highly expressed in a colorectal adenocarcinoma cell line

General

glycoprotein secreted protein

Properties

SIZE: MW = 52 kD entity length = 467 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-21} somatomedin B domain {50-98} MOTIF: cysteine residue {C54} MODIFICATION: cysteine residue {C73} cysteine residue {C71} MODIFICATION: cysteine residue {C85} cysteine residue {C71} MODIFICATION: cysteine residue {C73} cysteine residue {C73} MODIFICATION: cysteine residue {C54} cysteine residue {C73} MODIFICATION: cysteine residue {C71} cysteine residue {C77} MODIFICATION: cysteine residue {C84} N-glycosylation site {N78} cysteine residue {C84} MODIFICATION: cysteine residue {C77} cysteine residue {C85} MODIFICATION: cysteine residue {C71} cysteine residue {C85} MODIFICATION: cysteine residue {C92} cysteine residue {C92} MODIFICATION: cysteine residue {C85} N-glycosylation site {N161}

Database Correlations

UniProt Q9GZM7 Pfam PF00112

References

UniProt :accession Q9GZM7