tubulointerstitial nephritis antigen (TIN-Ag, TINAG)

Function: - mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 & alphaV-beta3 Structure: - belongs to the peptidase C1 family - contains 1 SMB domain (somatomedin B domain) Compartment: extracellular matrix, basement membrane Alternative splicing: named isoforms=2 Expression: - expressed in the kidney cortex, small intestine, cornea - initially observed in the Bowman capsule during early glomerular capillary loop formation in kidney - in developmentally mature glomeruli, expression is higher in proximal tubular basement membrane than in distal basement membrane & Bowman capsule Pathology: - antibodies against TINAG are found in sera of patients with tubulointerstitial nephritis

General

glycoprotein matrix protein

Properties

SIZE: MW = 55 kD entity length = 476 aa COMPARTMENT: extracellular matrix MOTIF: N-glycosylation site {N38} proteolytic site {49-50} somatomedin B domain {59-107} MOTIF: cysteine residue {C63} MODIFICATION: cysteine residue {C70} cysteine residue {C70} MODIFICATION: cysteine residue {C63} cysteine residue {C70} MODIFICATION: cysteine residue {C102} cysteine residue {C81} MODIFICATION: cysteine residue {C95} cysteine residue {C81} MODIFICATION: cysteine residue {C83} cysteine residue {C83} MODIFICATION: cysteine residue {C81} cysteine residue {C87} MODIFICATION: cysteine residue {C94} cysteine residue {C94} MODIFICATION: cysteine residue {C87} cysteine residue {C95} MODIFICATION: cysteine residue {C81} cysteine residue {C95} MODIFICATION: cysteine residue {C102} cysteine residue {C102} MODIFICATION: cysteine residue {C70} cysteine residue {C102} MODIFICATION: cysteine residue {C95} N-glycosylation site {N175} N-glycosylation site {N314} N-glycosylation site {N360} N-glycosylation site {N455}

Database Correlations

OMIM 606749 UniProt Q9UJW2 Pfam PF00112

References

UniProt :accession Q9UJW2