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tubulin-tyrosine ligase (TTL)
Function:
- catalyzes the posttranslational addition of Tyr to the C-terminal end of detyrosinated alpha-tubulin
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
Cofactor: Mg+2, K+
Structure:
1) monomer
2) contains 1 TTL domain
General
tyrosine kinase (protein tyrosine kinase, PTK)
Properties
SIZE: MW = 43 kD
entity length = 377 aa
STATE: active state
MOTIF: TTL {3-370}
Database Correlations
OMIM 608291
UniProt Q8NG68
Pfam PF03133
ENZYME 6.3.2.25
References
UniProt :accession Q8NG68