tubulin polymerization-promoting protein (TPPP, 25 kD brain-specific protein, p25-alpha, p24, p25)

Function: 1) promotes in vitro polymerization of tubulin into double- walled tubules & polymorphic aggregates or bundled stabilized microtubule blocks 2) may form dimers 3) binds tubulin, binding inhibited by GTP 4) interacts with GSK3, poor substrate for GSK3 5) phosphorylated by TPK2 Expression: widely expressed Pathology: - when overexpressed, inhibits mitotic spindle assembly & nuclear envelope breakdown, apparently without affecting other cellular event

General

glycoprotein phosphoprotein tubulin polymerization-promoting protein family (TPPP family)

Properties

SIZE: MW = 24 kD entity length = 219 aa MOTIF: Thr phosphorylation site {T14} Ser phosphorylation site {S18} Ser phosphorylation site {S32} Ser glycosylation site {S152}

Database Correlations

OMIM 608773 UniProt O94811 Pfam PF05517

References

UniProt :accession O94811