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tuberoinfundibular peptide of 39 residues (TIP39, TIPF39)
Function:
1) role as selective agonist of PTHR2 with adenyl cyclase activation & intracellular Ca+2 influx
2) induces protein kinase C beta activation, recruitment of beta-arrestin & PTH2R internalization
3) inhibits cell proliferation via PTHR2 activation (putative)
4) neuropeptide, activate nociceptors & nociceptive circuits (putative)
5) role in spermatogenesis (putative)
Structure:
- belongs to the parathyroid hormone family
Compartment: secreted
Expression:
- expressed in fetal & adult brain, cerebellum, trachea > spinal cord, fetal liver, kidney, heart
General
secreted protein
Properties
SIZE: MW = 11 kD
entity length = 100 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-30}
Database Correlations
OMIM 608386
UniProt Q96A98
References
UniProt :accession Q96A98