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tuberculosis vaccine (M72/AS01E vaccine)
Indications:
- latent tuberculosis (50% effective over 3 years) [1,2]
Dosage:
- 2 doses 1 month apart
Mechanism of action:
- M72/AS01E vaccine contains 2 M tuberculosis proteins plus an adjuvant used in malaria vaccine & recombinant Herpes zoster vaccine
General
vaccine
References
- Van Der Meeren O, Hatherill M, Nduba V et al
Phase 2b Controlled Trial of M72/AS01E Vaccine to Prevent Tuberculosis.
N Engl J Med. Sept 25, 2018
PMID: 30280651 Free Article
https://www.nejm.org/doi/full/10.1056/NEJMoa1803484
- Bloom BR
New Promise for Vaccines against Tuberculosis.
N Engl J Med. Sept 25, 2018
PMID: 30252629 Free Article
https://www.nejm.org/doi/full/10.1056/NEJMe1812483
- Tait DR, Hatherill M, Van Der Meeren O et al
Final Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis.
N Engl J Med. Oct 29, 2019
PMID: 31661198
https://www.nejm.org/doi/full/10.1056/NEJMoa1909953