tubby-related protein 4; tubby superfamily protein; tubby-like protein 4 (TULP4, KIAA1397, TUBL4, TUSP)

Function: - may be a substrate-recognition component of an SCF-like ECS complex (elongin-Cullin-SOCS-box protein complex), an E3 ubiquitin ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins - protein modification; protein ubiquitination Structure: - the SOCS box domain mediates interaction with the elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (putative) - belongs to the TUB family - contains 1 SOCS box domain - contains 3 WD repeats Compartment: cytoplasm Alternative splicing: named isoforms=2 Expression: - expressed mainly in brain, skeletal muscle, testis & kidney

Properties

SIZE: entity length = 1543 aa MW = 169 kD COMPARTMENT: cytoplasm MOTIF: WD repeat {80-119} WD repeat {123-162} WD repeat {165-204} SOCS box domain {364-414} TUB {1466-1543}

Database Correlations

UniProt Q9NRJ4 PFAM correlations Entrez Gene 56995 Kegg hsa:56995

References

UniProt :accession Q9NRJ4