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TSC22 domain family protein 1 (transforming growth factor beta-1-induced transcript 4 protein, regulatory protein TSC-22, TGFB-stimulated clone 22 homolog, cerebral protein 2, TSC22D1 TGFB1I4 TSC22, hucep-2)
Function:
1) transcriptional repressor
2) acts on the C-type natriuretic peptide (CNP) promoter
3) homodimer or heterodimer; can form an heterodimer with TSC22D4
Compartment: cytoplasm, nucleus
Expression:
- widely expressed in fetal & adult tissues
- in aortic endothelial cells, induced by cytokines, including TGFB.
General
nuclear protein
Properties
SIZE: MW = 16 kD
entity length = 144 aa
COMPARTMENT: cell nucleus
MOTIF: leucine zipper
SITE: 77-98
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 607715
UniProt Q15714
Pfam PF01166
References
UniProt :accession Q15714