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trypsin-6 (trypsinogen C, TRY6, T6)
Function:
- preferential cleavage: Arg-|-Xaa, Lys-|-Xaa
Structure:
- belongs to the peptidase S1 family, tryptase subfamily
- contains 1 peptidase S1 domain
Compartment: secreted (putative)
Expression:
- overexpressed in metastasing in non-small-cell lung cancer, leading to an enhanced cell migration
Genetics:
- could be the product of a pseudogene
- although being similar to trypsinogen, it appears to be a transcribed pseudogene
General
Ca+2 binding protein
trypsin
Properties
COMPARTMENT: extracellular compartment
SIZE: entity length = 247 aa
MW = 27 kD
MOTIF: signal sequence {1-15}
S1 domain {24-244}
MOTIF: cysteine residue {C48}
MODIFICATION: cysteine residue {C64}
histidine residue {H63}
cysteine residue {C64}
MODIFICATION: cysteine residue {C48}
Ca+2-binding site
SITE: 75-75
Ca+2-binding site
SITE: 77-77
Ca+2-binding site
SITE: 80-80
Ca+2-binding site
SITE: 85-85
aspartate residue {D107}
cysteine residue {C139}
MODIFICATION: cysteine residue {C206}
cysteine residue {C171}
MODIFICATION: cysteine residue {C185}
cysteine residue {C185}
MODIFICATION: cysteine residue {C171}
aspartate residue {194}
cysteine residue {C196}
MODIFICATION: cysteine residue {C220}
serine residue {S200}
cysteine residue {C206}
MODIFICATION: cysteine residue {C139}
cysteine residue {C220}
MODIFICATION: cysteine residue {C196}
STATE: active state
Database Correlations
UniProt Q8NHM4
Pfam PF00089
ENZYME 3.4.21.4
References
UniProt :accession Q8NHM4