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trypsin-2; anionic trypsinogen; serine protease 2; trypsin II (PRSS2, TRY2 ,TRYP2)
Function:
- preferential cleavage: Arg-|-Xaa, Lys-|-Xaa
- sulfated on Tyr
Cofactor: binds 1 Ca+2 per subunit (putative)
Structure:
- belongs to the peptidase S1 family
- contains 1 peptidase S1 domain
Compartment: secreted, extracellular space
General
Ca+2 binding protein
phosphoprotein
trypsin
Properties
SIZE: entity length = 247 aa
MW = 26 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-15}
MOTIF: Thr phosphorylation site {T8}
S1 domain {24-244}
MOTIF: cysteine residue {C30}
MODIFICATION: cysteine residue {C160}
cysteine residue {C48}
MODIFICATION: cysteine residue {C64}
histidine residue {H63}
cysteine residue {C64}
MODIFICATION: cysteine residue {C48}
Ca+2-binding site
SITE: 75-75
Ca+2-binding site
SITE: 77-77
Ca+2-binding site
SITE: 80-80
Ca+2-binding site
SITE: 85-85
aspartate residue {D107}
cysteine residue {C160}
MODIFICATION: cysteine residue {C30}
cysteine residue {C171}
MODIFICATION: cysteine residue {C185}
cysteine residue {C185}
MODIFICATION: cysteine residue {C171}
aspartate residue {194}
cysteine residue {C196}
MODIFICATION: cysteine residue {C220}
serine residue {S200}
cysteine residue {C220}
MODIFICATION: cysteine residue {C196}
STATE: active state
Database Correlations
OMIM 601564
MORBIDMAP 601564
UniProt P07478
Pfam PF00089
Entrez Gene 5645
KEGG correlations
ENZYME 3.4.21.4
References
UniProt :accession P15951