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tropomyosin-beta; tropomyosin-2; beta-tropomyosin (TPM2, TMSB)
Function:
- binds to actin filaments in muscle & non-muscle cells
- role, in association with troponin complex, in Ca+2 dependent regulation of vertebrate striated muscle contraction
- smooth muscle contraction is regulated by interaction with caldesmon
- in non-muscle cells, implicated in stabilizing cytoskeleton actin filaments
Structure:
- heterodimer of an alpha & a beta chain
- the molecule is in a coiled coil structure that is formed by 2 polypeptide chains
- prominent 7-residue periodicity
- belongs to the tropomyosin family
Compartment: cytoplasm, cytoskeleton
Alternative splicing: named isoforms=3
Expression:
- skeletal muscle
- absent from normal breast tissue
Pathology:
- present in primary breast cancer tissue; absent from normal breast tissue
- defects in TPM2 are the cause of
a) nemaline myopathy type 4
b) arthrogryposis multiplex congenita, distal, type 1
General
tropomyosin
Properties
SIZE: entity length = 284 aa
MW = 33 kD
COMPARTMENT: cytoplasm
MOTIF: coiled coil {1-284}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Thr phosphorylation site {T252}
Ser phosphorylation site {S283}
Database Correlations
OMIM correlations
MORBIDMAP correlations
UniProt P07951
Pfam PF00261
Entrez Gene 7169
Kegg hsa:7169
References
- UniProt :accession P07951
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=TPM2
- OMIM :accession 190990
- Harris RA
Cluster analysis of an extensive human breast cancer
cell line protein expression map database.
Proteomics. 2002 Feb;2(2):212-23.
PMID: 11840567