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tropomodulin-1; erythrocyte tropomodulin; E-Tmod (TMOD1, D9S57E, TMOD)
Function:
- blocks elongation & depolymerization of actin filaments at the pointed end
- the Tmod/TM complex contributes to formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton
- may play a role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus
- binds to the N-terminus of isoforms 2/3 of TPM3 & to actin
Structure: belongs to the tropomodulin family
Compartment: cytoplasm, cytoskeleton
Expression:
- highly expressed in the erythrocyte, heart & skeletal muscle
General
tropomodulin
Properties
SIZE: entity length = 359 aa
MW = 41 kD
COMPARTMENT: cytoplasm
MOTIF: binding site
SITE: 39-138
FOR-BINDING-OF: tropomyosin
Database Correlations
OMIM 190930
UniProt P28289
Pfam PF03250
Entrez Gene 7111
Kegg hsa:7111
References
UniProt :accession P28289