tRNA-splicing ligase RtcB homolog (RTCB, C22orf28, HSPC117)

Function: - catalytic subunit of the tRNA-splicing ligase complex - acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into mature tRNA as a canonical 3',5'-phosphodiester - may act as a RNA ligase with broad substrate specificity ATP + (ribonucleotide)(n) + (ribonucleotide)(m) = AMP + diphosphate + (ribonucleotide)(n+m) Structure: belongs to the RtcB family Compartment: cytoplasm (putative)

General

enzyme catalytic subunit ligase or synthetase metalloprotein

Properties

SIZE: entity length = 505 aa MW = 55 kD COMPARTMENT: cytoplasm MOTIF: Zn+2-binding site SITE: 122-122 Zn+2-binding site SITE: 227-227 active site Zn+2-binding site SITE: 259-259

Database Correlations

OMIM 613901 UniProt Q9Y3I0 Pfam PF01139 Entrez Gene 51493 Kegg hsa:51493 ENZYME 6.5.1.3

References

UniProt :accession Q9Y3I0