tRNA-splicing endonuclease subunit sen2; tRNA-intron endonuclease sen2; Hssen2 (TSEN2 SEN2)

Function: 1) one of 2 catalytic subunits of tRNA-splicing endonuclease 2) isoform 2 is a component of a complex with SEN54, but low level of SEN15 & SEN34 3) phosphorylated upon DNA damage, probably by ATM or ATR Structure: belongs to the tRNA-intron endonuclease family Compartment: nuclear; may be transiently localized in nucleolus Alternative splicing: named isoforms=3 Expression: - isoform 1 & isoform 2 are widely expressed at very low level Pathology: - defects in TSEN2 are the cause of pontocerebellar hypoplasia type 2B

General

endonuclease enzyme catalytic subunit nuclear protein phosphoprotein

Properties

SIZE: entity length = 465 aa MW = 53 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S240} tyrosine residue {Y369} histidine residue {H377} Ser phosphorylation site {S408} Ser phosphorylation site {S411} Ser phosphorylation site {S415} lysine residue {K416}

Database Correlations

OMIM correlations UniProt Q8NCE0 PFAM correlations Entrez Gene 80746 Kegg hsa:80746 ENZYME 3.1.27.9

References

UniProt :accession Q8NCE0