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tRNA selenocysteine-associated protein 1 (SECp43, TRSPAP1, SECP43, TRNAU1AP)
Function:
- role in the early steps of selenocysteine biosynthesis & tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins
- stabilizes the SECISBP2, EEFSEC & tRNA(Sec) complex
- may be involved in the methylation of tRNA(Sec)
- enhances efficiency of selenoproteins synthesis (putative)
- component of the tRNA(Sec) complex
- interacts with SEPSECS
- associates with mRNP &/or polysomes (putative)
Structure:
- belongs to the RRM TRSPAP family
- contains 2 RRM (RNA recognition motif) domains
Compartment:
- nucleus, cytoplasm
- abundant in the nucleus (putative)
Alternative splicing: named isoforms=2
General
nuclear protein
RNA-binding protein
Properties
SIZE: entity length = 287 aa
MW = 32 kD
COMPARTMENT: cell nucleus
MOTIF: RNP motif
NAME: RNP motif
SITE: 3-86
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
RNP motif
NAME: RNP motif
SITE: 96-175
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
Database Correlations
UniProt Q9NX07
Pfam PF00076
References
UniProt :accession Q9NX07