tRNA-dihydrouridine synthase 2-like (hDUS2, up-regulated in lung cancer, URLC8, DUS2L, DUS2)

Function: - dihydrouridine synthase - catalyzes synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs - interacts with EPRS Cofactor: FAD Structure: - belongs to the dus family, Dus2 subfamily - contains 1 DRBM domain (double-stranded RNA-binding) Compartment: - cytoplasm, endoplasmic reticulum - mainly at the endoplasmic reticulum Expression: - weak expression in heart, placenta, skeletal muscle Pathology: - p-regulated in most lung cancer cells (at protein level)

General

flavoprotein oxidoreductase RNA-binding protein

Properties

SIZE: MW = 55 kD entity length = 493 aa COMPARTMENT: cytoplasm endoplasmic reticulum MOTIF: DRBM {369-436}

Database Correlations

UniProt Q9NX74 PFAM correlations

References

UniProt :accession Q9NX74