tRNA (adenine-N(1)-)-methyltransferase

Function: - catalyzes formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA S-adenosyl-L-methionine + tRNA S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine Structure: heterodimer of TRM6 & TRM61

General

methyltransferase molecular complex

Properties

MOTIF: active site SUBUNITS: tRNA(m1A58)-methyltransferase subunit TRM6 COMPARTMENT: cell nucleus MOTIF: Thr phosphorylation site {T107} tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61 COMPARTMENT: cell nucleus MOTIF: active site

References

UniProt :accession Q9NZI8, Q9BZF9

Components

tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61; tRNA(m1A58)-methyltransferase subunit TRM61; tRNA(m1A58)MTase subunit TRM61 (TRM61, TRMT61A, C14orf172) tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6; tRNA(m1A58)-methyltransferase subunit TRM6; tRNA(m1A58)MTase subunit TRM6 (TRM6, TRMT6, KIAA1153)