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tristetraproline; TTP; zinc finger protein 36 homolog; Zfp-36; protein TIS11A; TIS11; growth factor-inducible nuclear protein NUP475; G0/G1 switch regulatory protein 24 (ZFP36, G0S24, RNF162A, TIS11A, TTP)
Function:
- probable regulatory protein with a novel Zn+2 finger structure involved in regulating response to growth factors
- binds Zn+2
Structure: contains 2 C3H1-type Zn+2 fingers
Compartment: nucleus
Expression: induced by stimulation with various mitogens
General
DNA-binding protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 326 aa
MW = 34 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S60}
consensus repeat {71-75}
SEQUENCE-IS: PPPPG
Ser phosphorylation site {S88}
Ser phosphorylation site {S90}
Ser phosphorylation site {S93}
Zinc finger
NAME: Zinc finger
SITE: 103-131
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 141-169
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S186}
consensus repeat {198-202}
SEQUENCE-IS: PPPPG
consensus repeat {219-223}
SEQUENCE-IS: PPPPG
Thr phosphorylation site {T257}
Ser phosphorylation site {S323}
Database Correlations
OMIM 190700
UniProt P26651
Pfam PF00642
Entrez Gene 7538
Kegg hsa:7538
References
- UniProt :accession P26651
- NIEHS-SNPs
http://egp.gs.washington.edu/data/zfp36/