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trisomy X; triple X syndrome

Etiology: - not inherited - generally results from nondisjunction of oocytes or spermatocytes resulting in an extra X chromosome in the affected gamete Epidemiology: - occurs in 1/1000 newborn females Genetics: - 47, XXX karyotype - some females 3 X chromosomes in only some of their cells (46,XX/47,XXX mosaics) Clinical manifestations: - normal female phenotype - may be taller than average

Related

trisomy X testing; gene XXX mutations (in Loinc)

General

genetic syndrome (multisystem disorder) trisomy

References

  1. Wikipedia: Triple X syndrome http://en.wikipedia.org/wiki/Triple_X_syndrome
  2. Genetics Home Reference http://ghr.nlm.nih.gov/condition/triple-x-syndrome
  3. University of Michigan: XXX Syndrome (Trisomy X) http://www.med.umich.edu/yourchild/topics/xxxsyn.htm
  4. Mayo Clinic: Triple X syndrome http://www.mayoclinic.com/health/triple-x-syndrome/DS01090/DSECTION=causes