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tripartite motif-containing protein 66 (TRIM66, C11orf29, KIAA0298)
Function:
- may function as transcription repressor
- repressive effects are mediated, at least in part, by recruitment of deacetylase activity
- may play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation & centromere association (putative)
- can form homo- & heterodimers
- interacts with CBX5, CBX1 & CBX3 via PxVxL motif (putative)
Structure:
- contains 2 B box-type Zn+2 fingers
- contains 1 bromo domain
- contains 1 PHD-type Zn+2 finger
Compartment:
- nucleus
- forms discrete foci within the centromeric chromocenter & surrounding nucleoplasm
Alternative splicing: named isoforms=2
General
nuclear protein
zinc finger protein
Properties
SIZE: entity length = 1216 aa
MW = 135 kD
COMPARTMENT: cell nucleus
MOTIF: zinc finger B box
SITE: 1-46
EFFECTOR-BOUND: Zn+2
zinc finger B box
SITE: 60-101
EFFECTOR-BOUND: Zn+2
coiled coil {130-200}
glutamine-rich region {384-571}
MOTIF: glutamine residue (SEVERAL)
proline-rich region
SITE: 453-499
MOTIF: proline residue (SEVERAL)
PxVxL {860-864}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 970-1017
EFFECTOR-BOUND: Zn+2
bromodomain {1056-1128}
Database Correlations
OMIM 612000
UniProt O15016
PFAM correlations
Entrez Gene 9866
Kegg hsa:9866
References
UniProt :accession O15016