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triosephosphate isomerase (TIM, triose-phosphate isomerase) (TPI1 TPI)
Function:
- catalyzes interconversion of glyceraldehyde-3-phosphate & dihydroxyacetone phosphate
- carbohydrate biosynthesis; gluconeogenesis
- carbohydrate degradation; glycolysis
- D-glyceraldehyde 3-phosphate from glycerone phosphate, step 1/1
D-glyceraldehyde-3-phosphate glycerone-phosphate
Structure:
- homodimer
- belongs to the triosephosphate isomerase family
Alternative splicing: named isoforms=2 (Alternative splicing seems doubtful, since exon-intron junctions are not the consensus ones)
Pathology:
- defects in TPI1 are the cause of triosephosphate isomerase deficiency
Interactions
molecular events
Related
gluconeogenesis
glycolytic pathway (glycolysis, Embden Myerhof pathway)
General
glycolytic enzyme
isomerase
oligomerizing protein
phosphoprotein
Properties
SIZE: entity length = 249 aa
MW = 27 kD
COMPARTMENT: cytoplasm
MOTIF: binding site
SITE: 12-12
FOR-BINDING-OF: Substrate
binding site
SITE: 14-14
FOR-BINDING-OF: Substrate
Ser phosphorylation site {S21}
histidine residue {H96}
glutamate residue {E166}
Database Correlations
OMIM 190450
MORBIDMAP 190450
UniProt P60174
Pfam PF00121
ENZYME 5.3.1.1
References
- UniProt :accession P60174
- Wikipedia; note=triosephosphate isomerase entry
http://en.wikipedia.org/wiki/triosephosphate_isomerase