trimethadione (Tridione)

Tradename: Tridione. Indications: - seizures: absence (petit mal) - atypical absence (intractable seizures only) Dosage: - 900-1200 mg PO QD. Pharmacokinetics: - demethylated to dimethadione (active metabolite) - 1/2 life of dimethadione (active metabolite) is 6-13 days Adverse effects: 1) Neurologic: sedation, blurred vision 2) Systemic: skin rash, bone marrow suppression, nephrosis, hepatitis

Interactions

drug interactions drug adverse effects of anticonvulsants monitor with anticonvulsants

Related

diimethadione (Dimethadion, Eupractone) trimethadione in body fluid

General

anticonvulsant oxazole; 1,3 oxazole

Properties

MISC-INFO: 1/2life 6-13 DAYS therapeutic-range 700 UG/ML protein-binding <5%

References

Harrison's Principles of Internal Medicine, 13th ed. Companion Handbook. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1995, pg 701.