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trimetazidine
Not approved for use in U.S.
Indications:
- treatment of angina pectoris in Europe & Russia
- treatment of vertigo, tinnitus
Pharmacokinetics:
- 1/2 life 8 hours, 12 hours in the elderly
- most excreted in the urine unaltered
Mechanism of action:
- inhibits fatty acid oxidation, shifting metabolism towards glucose oxidation, thus cells more efficient in hypoxic environment
Notes:
- Olympic controversy, Russian skater Kamila Valieva tested positive for trimetazidine
- use may give athletes an edge
General
vasodilator
Database Correlations
PUBCHEM cid=21109
References
- Yang J, Zhang L, Liu C et al
Trimetazidine attenuates high-altitude fatigue and cardiorespiratory fitness
impairment: A randomized double-blinded placebo-controlled clinical trial.
Biomed Pharmacother. 2019. Aug;116:109003
PMID: 31125823 Free article
https://www.sciencedirect.com/science/article/pii/S0753332219310261
- Howes L
What is trimetazidine and why is it banned in Olympic competition?
Chemical ^ Engeineering News. Feb 17, 2022
https://cen.acs.org/analytical-chemistry/forensic-science/trimetazidine-banned-Olympic-competition/100/web/2022/02