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trilisate (choline magnesium trisalicylate)
Salicylate combination.
Indications:
1) osteoarthritis
2) rheumatoid arthritis
3) analgesic for mild to moderate pain
Contraindications:
Caution:
- avoid use in patients with suspected varicella or influenza, especially in children; cases of Reye's syndrome have occurred
pregnancy-category C)
safety in lactation ?
Dosage:
1) adults:
a) 1 tab PO every 4-8 hours
b) 750 mg PO every 8 hours
c) 1.5 g PO every 12 hours
2) children: 30-60 mg/kg//day divided TID-QID
Tabs: 500, 750, 1000 mg.
Liquid: 500 mg/5 mL
Pharmacokinetics: elimination: kidney.
Adverse effects:
1) common (> 10%)
- nausea, heartburn, stomach pains, dyspepsia, epigastric discomfort
2) less common (1-10%)
- weakness, tiredness, hemolytic anemia, skin rash, dyspnea, gastrointestinal ulceration, anaphylactic shock
3) uncommon (< 1%)
- insomnia, nervousness, 'jitters', occult bleeding, prolongation of bleeding time, leukopenia, thrombocytopenia, hepatotoxicity, bronchospasm, iron-deficiency anemia, impaired renal function
Drug interactions:
1) may enhance hypothrombinemic effects of warfarin
2) may increase methotrexate serum levels & toxicity
Interactions
drug interactions
General
pharmacologic combination
Database Correlations
PUBCHEM cid=47361
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
Components
choline
Mg+2
salicylate