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triggering receptor expressed on myeloid cells 1; triggering receptor expressed on monocytes 1; TREM-1 (TREM1)
Function:
1) stimulates neutrophil & monocyte-mediated inflammatory responses
2) triggers release of pro-inflammatory chemokines & cytokines
3) increases surface expression of inflammatory cell activation markers
4) amplifies inflammatory responses triggered by bacterial & fungal infections
5) mediator of septic shock
6) interacts with TYROBP
Structure:
- glycosylated
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment:
- isoform 1: cell membrane
- isoform 2: secreted
Alternative splicing: named isoforms=2
Expression:
- expressed in adult liver, lung, spleen, lymph node, placenta, spinal cord, heart tissues
- expressed in peripheral blood leukocytes > bone marrow
- expressed in normal cells > malignant cells
- expressed with differentiation of monocytes
Pathology:
- up-regulated by bacteria, fungi, lipopolysaccharides
- strongly expressed in acute inflammatory lesions caused by bacteria, fungi
General
triggering receptor expressed on myeloid cells
Properties
SIZE: MW = 26 kD
entity length = 234 aa
MOTIF: signal sequence {1-20}
immunoglobulin superfamily domain {26-134}
MOTIF: cysteine residue {C41}
MODIFICATION: cysteine residue {C113}
cysteine residue {C113}
MODIFICATION: cysteine residue {C41}
N-glycosylation site {N146}
N-glycosylation site {N191}
N-glycosylation site {N194}
transmembrane domain {206-226}
Database Correlations
OMIM 605085
UniProt Q9NP99
Pfam PF07686
Entrez Gene 54210
Kegg hsa:5421
References
- Entrez Gene :accession 54210
- UniProt :accession Q9NP99